Job Title: Sr. Research Scientist – Biochemistry
Location: Onsite, Wilmington, DE
Position Overview
We are seeking a highly skilled Sr. Research Scientist – Biochemistry to support drug discovery efforts through the design, development, and execution of biochemical and biophysical assays. This role will play a critical part in hit identification, validation, and mechanistic studies for small molecules and other therapeutic modalities.
Key Responsibilities
- Design, develop, and execute biochemical assays (e.g., FI, HTRF, FP) and biophysical assays (e.g., SPR, BLI, ITC, DSF)
- Conduct high-throughput screening (HTS) to evaluate compound libraries and characterize binding kinetics (IC₅₀, Kd, kon, koff)
- Troubleshoot assay performance, optimizing for robustness, reproducibility, and scalability
- Analyze and interpret experimental data using tools such as GraphPad Prism and Genedata
- Support protein expression and purification workflows using chromatography techniques (affinity, ion-exchange, size-exclusion)
- Operate and maintain lab instrumentation including plate readers and automated liquid handling systems
- Maintain accurate documentation using electronic lab notebooks (ELN) and contribute to technical reports and presentations
Required Qualifications
- Bachelor’s, Master’s, or Ph.D. in Biochemistry, Chemistry, Biophysics, Chemical Biology, or related field
- Strong foundation in enzymology and assay development
- Hands-on experience in protein purification and biochemical/biophysical characterization
- Proficiency with data analysis tools (GraphPad Prism, Genedata, or similar)
- Experience working in a laboratory setting with strong attention to detail and documentation
